| Reprogramming to recover youthful epigenetic information and restore vision Y Lu, B Brommer, X Tian, A Krishnan, M Meer, C Wang, DL Vera, Q Zeng, ... Nature 588 (7836), 124-129, 2020 | 532 | 2020 |
| Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases AE Kane, DA Sinclair Circulation research 123 (7), 868-885, 2018 | 357 | 2018 |
| Loss of epigenetic information as a cause of mammalian aging JH Yang, M Hayano, PT Griffin, JA Amorim, MS Bonkowski, ... Cell 186 (2), 305-326. e27, 2023 | 249 | 2023 |
| Epigenetic changes during aging and their reprogramming potential AE Kane, DA Sinclair Critical reviews in biochemistry and molecular biology 54 (1), 61-83, 2019 | 222 | 2019 |
| Impact of longevity interventions on a validated mouse clinical frailty index AE Kane, SN Hilmer, D Boyer, K Gavin, D Nines, SE Howlett, R De Cabo, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2016 | 129 | 2016 |
| Age and life expectancy clocks based on machine learning analysis of mouse frailty MB Schultz, AE Kane, SJ Mitchell, MR MacArthur, E Warner, DS Vogel, ... Nature communications 11 (1), 4618, 2020 | 105 | 2020 |
| Frailty biomarkers in humans and rodents: current approaches and future advances AE Kane, DA Sinclair Mechanisms of Ageing and Development 180, 117-128, 2019 | 88 | 2019 |
| Differences in cardiovascular aging in men and women AE Kane, SE Howlett Sex-specific analysis of cardiovascular function, 389-411, 2018 | 76 | 2018 |
| Chronic treatment with the ACE inhibitor enalapril attenuates the development of frailty and differentially modifies pro-and anti-inflammatory cytokines in aging male and … K Keller, A Kane, S Heinze-Milne, SA Grandy, SE Howlett The Journals of Gerontology: Series A 74 (8), 1149-1157, 2019 | 73 | 2019 |
| A murine frailty index based on clinical and laboratory measurements: links between frailty and pro-inflammatory cytokines differ in a sex-specific manner AE Kane, KM Keller, S Heinze-Milne, SA Grandy, SE Howlett The Journals of Gerontology: Series A 74 (3), 275-282, 2019 | 67 | 2019 |
| Adverse geriatric outcomes secondary to polypharmacy in a mouse model: the influence of aging A Huizer-Pajkos, AE Kane, SE Howlett, J Mach, SJ Mitchell, R De Cabo, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2016 | 67 | 2016 |
| Sex differences in frailty: comparisons between humans and preclinical models AE Kane, SE Howlett Mechanisms of Ageing and Development 198, 111546, 2021 | 66 | 2021 |
| The association between frailty, the metabolic syndrome, and mortality over the lifespan AE Kane, E Gregson, O Theou, K Rockwood, SE Howlett Geroscience 39, 221-229, 2017 | 63 | 2017 |
| Sex differences in the response to dietary restriction in rodents AE Kane, DA Sinclair, JR Mitchell, SJ Mitchell Current opinion in physiology 6, 28-34, 2018 | 60 | 2018 |
| Age-related changes in the hepatic pharmacology and toxicology of paracetamol SJ Mitchell, AE Kane, SN Hilmer Current gerontology and geriatrics research 2011, 2011 | 60 | 2011 |
| Animal models of frailty: current applications in clinical research AE Kane, SN Hilmer, J Mach, SJ Mitchell, R de Cabo, SE Howlett Clinical interventions in aging, 1519-1529, 2016 | 58 | 2016 |
| ARDD 2020: from aging mechanisms to interventions GV Mkrtchyan, K Abdelmohsen, P Andreux, I Bagdonaite, N Barzilai, ... Aging (Albany NY) 12 (24), 24484, 2020 | 54 | 2020 |
| The impact of age and frailty on ventricular structure and function in C57BL/6J mice HA Feridooni, AE Kane, O Ayaz, A Boroumandi, N Polidovitch, ... The Journal of physiology 595 (12), 3721-3742, 2017 | 53 | 2017 |
| Sex differences in healthspan predict lifespan in the 3xTg-AD mouse model of Alzheimer’s disease AE Kane, S Shin, AA Wong, E Fertan, NS Faustova, SE Howlett, ... Frontiers in aging neuroscience 10, 172, 2018 | 51 | 2018 |
| Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice J Mach, G Gemikonakli, C Logan, B Vander Wyk, H Allore, ... The Journals of Gerontology: Series A 76 (6), 1010-1018, 2021 | 49 | 2021 |
Susan HowlettDalhousie UniversityVerified email at dal.ca
