Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes L Alvarez-Erviti, Y Seow, HF Yin, C Betts, S Lakhal, MJA Wood Nature biotechnology 29 (4), 341-345, 2011 | 4766 | 2011 |
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting OPB Wiklander, JZ Nordin, A O'Loughlin, Y Gustafsson, G Corso, I Mäger, ... Journal of extracellular vesicles 4 (1), 26316, 2015 | 1408 | 2015 |
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission L Alvarez-Erviti, Y Seow, AH Schapira, C Gardiner, IL Sargent, MJA Wood, ... Neurobiology of disease 42 (3), 360-367, 2011 | 833 | 2011 |
Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties JZ Nordin, Y Lee, P Vader, I Mäger, HJ Johansson, W Heusermann, ... Nanomedicine: Nanotechnology, Biology and Medicine 11 (4), 879-883, 2015 | 702 | 2015 |
Exosome-mediated delivery of siRNA in vitro and in vivo S El-Andaloussi, Y Lee, S Lakhal-Littleton, J Li, Y Seow, C Gardiner, ... Nature protocols 7 (12), 2112-2126, 2012 | 613 | 2012 |
Biological gene delivery vehicles: beyond viral vectors Y Seow, MJ Wood Molecular therapy 17 (5), 767-777, 2009 | 432 | 2009 |
Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy X Gao, N Ran, X Dong, B Zuo, R Yang, Q Zhou, HM Moulton, Y Seow, ... Science translational medicine 10 (444), eaat0195, 2018 | 318 | 2018 |
Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function HF Yin, HM Moulton, Y Seow, C Boyd, J Boutilier, P Iverson, MJA Wood Human molecular genetics 17 (24), 3909-3918, 2008 | 307 | 2008 |
Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease L Alvarez-Erviti, Y Seow, AHV Schapira, MC Rodriguez-Oroz, JA Obeso, ... Cell death & disease 4 (3), e545-e545, 2013 | 244 | 2013 |
Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science PA Guerette, S Hoon, Y Seow, M Raida, A Masic, FT Wong, VHB Ho, ... Nature biotechnology 31 (10), 908-915, 2013 | 202 | 2013 |
Exosome-mediated miR-29 transfer reduces muscle atrophy and kidney fibrosis in mice H Wang, B Wang, A Zhang, F Hassounah, Y Seow, M Wood, F Ma, ... Molecular Therapy 27 (3), 571-583, 2019 | 171 | 2019 |
Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice HF Yin, AF Saleh, C Betts, P Camelliti, Y Seow, S Ashraf, A Arzumanov, ... Molecular therapy 19 (7), 1295-1303, 2011 | 171 | 2011 |
Systemic exosomal delivery of shRNA minicircles prevents parkinsonian pathology M Izco, J Blesa, M Schleef, M Schmeer, R Porcari, R Al-Shawi, ... Molecular Therapy 27 (12), 2111-2122, 2019 | 170 | 2019 |
Novel RNA-based strategies for therapeutic gene silencing CR Sibley, Y Seow, MJA Wood molecular Therapy 18 (3), 466-476, 2010 | 166 | 2010 |
A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice HF Yin, HM Moulton, C Betts, Y Seow, J Boutilier, PL Iverson, MJA Wood Human molecular genetics 18 (22), 4405-4414, 2009 | 158 | 2009 |
The biogenesis and characterization of mammalian microRNAs of mirtron origin CR Sibley, Y Seow, S Saayman, KK Dijkstra, S El Andaloussi, ... Nucleic acids research 40 (1), 438-448, 2012 | 141 | 2012 |
Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores BT Jacques-Fricke, Y Seow, PA Gottlieb, F Sachs, TM Gomez Journal of Neuroscience 26 (21), 5656-5664, 2006 | 134 | 2006 |
Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO HF Yin, HM Moulton, C Betts, T Merritt, Y Seow, S Ashraf, QS Wang, ... Molecular Therapy 18 (10), 1822-1829, 2010 | 86 | 2010 |
Diaphragm rescue alone prevents heart dysfunction in dystrophic mice A Crisp, HF Yin, A Goyenvalle, C Betts, HM Moulton, Y Seow, A Babbs, ... Human molecular genetics 20 (3), 413-421, 2011 | 80 | 2011 |
Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse HF Yin, C Betts, AF Saleh, GD Ivanova, H Lee, Y Seow, D Kim, MJ Gait, ... Molecular Therapy 18 (4), 819-827, 2010 | 79 | 2010 |