| The importance of synthetic chemistry in the pharmaceutical industry KR Campos, PJ Coleman, JC Alvarez, SD Dreher, RM Garbaccio, ... Science 363 (6424), eaat0805, 2019 | 413 | 2019 |
| Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease. RL DesJarlais, GL Seibel, ID Kuntz, PS Furth, JC Alvarez, ... Proceedings of the National Academy of Sciences 87 (17), 6644-6648, 1990 | 372 | 1990 |
| Structure-based design of estrogen receptor-β selective ligands ES Manas, RJ Unwalla, ZB Xu, MS Malamas, CP Miller, HA Harris, ... Journal of the American Chemical Society 126 (46), 15106-15119, 2004 | 212 | 2004 |
| High-throughput docking as a source of novel drug leads JC Alvarez Current opinion in chemical biology 8 (4), 365-370, 2004 | 203 | 2004 |
| Virtual screening in drug discovery J Alvarez, B Shoichet CRC press, 2005 | 191 | 2005 |
| Current and future roles of artificial intelligence in medicinal chemistry synthesis TJ Struble, JC Alvarez, SP Brown, M Chytil, J Cisar, RL DesJarlais, ... Journal of medicinal chemistry 63 (16), 8667-8682, 2020 | 164 | 2020 |
| Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design DHH Tsao, AG Sutherland, LD Jennings, Y Li, TS Rush III, JC Alvarez, ... Bioorganic & medicinal chemistry 14 (23), 7953-7961, 2006 | 115 | 2006 |
| Pharmacophore‐based molecular docking to account for ligand flexibility D Joseph‐McCarthy, BE Thomas IV, M Belmarsh, D Moustakas, ... Proteins: Structure, Function, and Bioinformatics 51 (2), 172-188, 2003 | 112 | 2003 |
| Application of a high-throughput screening procedure with PEG-induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal … TJ Gibson, K Mccarty, IJ Mcfadyen, E Cash, P Dalmonte, KD Hinds, ... Journal of pharmaceutical sciences 100 (3), 1009-1021, 2011 | 103 | 2011 |
| ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy JE Lopes, JL Fisher, HL Flick, C Wang, L Sun, MS Ernstoff, JC Alvarez, ... Journal for immunotherapy of cancer 8 (1), 2020 | 101 | 2020 |
| Structure-based design of carboxybiphenylindole inhibitors of the ZipA–FtsZ interaction AG Sutherland, J Alvarez, W Ding, KW Foreman, CH Kenny, ... Organic & biomolecular chemistry 1 (23), 4138-4140, 2003 | 61 | 2003 |
| Towards ambient temperature-stable vaccines: the identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay LD Schlehuber, IJ McFadyen, Y Shu, J Carignan, WP Duprex, WR Forsyth, ... Vaccine 29 (31), 5031-5039, 2011 | 60 | 2011 |
| Quinic Acid Derivatives as Sialyl Lewisx-Mimicking Selectin Inhibitors: Design, Synthesis, and Crystal Structure in Complex with E-Selectin N Kaila, WS Somers, BE Thomas, P Thakker, K Janz, S DeBernardo, ... Journal of medicinal chemistry 48 (13), 4346-4357, 2005 | 57 | 2005 |
| β-C-Mannosides as selectin inhibitors N Kaila, L Chen, D Tsao, S Tam, PW Bedard, RT Camphausen, ... Journal of Medicinal Chemistry 45 (8), 1563-1566, 2002 | 56 | 2002 |
| Automated generation of MCSS‐derived pharmacophoric DOCK site points for searching multiconformation databases D Joseph‐McCarthy, JC Alvarez Proteins: Structure, Function, and Bioinformatics 51 (2), 189-202, 2003 | 54 | 2003 |
| Hydrates and solid-state reactivity: a survey of β-lactam antibiotics MB Hickey, ML Peterson, ES Manas, J Alvarez, F Haeffner, Ö Almarsson Journal of pharmaceutical sciences 96 (5), 1090-1099, 2007 | 51 | 2007 |
| Experimental error, kurtosis, activity cliffs, and methodology: What limits the predictivity of quantitative structure–activity relationship models? RP Sheridan, P Karnachi, M Tudor, Y Xu, A Liaw, F Shah, AC Cheng, ... Journal of Chemical Information and Modeling 60 (4), 1969-1982, 2020 | 41 | 2020 |
| Thianthrene 5-oxide as a probe of the electrophilicity of hemoprotein oxidizing species JC Alvarez, PR Ortiz de Montellano Biochemistry 31 (35), 8315-8322, 1992 | 41 | 1992 |
| Structure–activity relationships of indole cytosolic phospholipase A2α inhibitors: substrate mimetics JC McKew, F Lovering, JD Clark, J Bemis, YB Xiang, M Shen, W Zhang, ... Bioorganic & medicinal chemistry letters 13 (24), 4501-4504, 2003 | 31 | 2003 |
| Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors N Kaila, BE Thomas IV, P Thakker, JC Alvarez, RT Camphausen, ... Bioorganic & medicinal chemistry letters 11 (2), 151-155, 2001 | 26 | 2001 |
