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Daniel Lietha
Daniel Lietha
Biological Research Center Margarita Salas (CIB-CSIC)
Verified email at cib.csic.es - Homepage
Title
Cited by
Cited by
Year
Structural basis for the autoinhibition of focal adhesion kinase
D Lietha, X Cai, DFJ Ceccarelli, Y Li, MD Schaller, MJ Eck
Cell 129 (6), 1177-1187, 2007
5602007
The FERM domain: organizing the structure and function of FAK
MC Frame, H Patel, B Serrels, D Lietha, MJ Eck
Nature reviews Molecular cell biology 11 (11), 802-814, 2010
4382010
Spatial and temporal regulation of focal adhesion kinase activity in living cells
X Cai, D Lietha, DF Ceccarelli, AV Karginov, Z Rajfur, K Jacobson, ...
Molecular and cellular biology, 2008
2202008
FAK structure and regulation by membrane interactions and force in focal adhesions
P Tapial Martínez, P López Navajas, D Lietha
Biomolecules 10 (2), 179, 2020
1822020
Phosphatidylinositol 4, 5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes
GM Gońi, C Epifano, J Boskovic, M Camacho-Artacho, J Zhou, ...
Proceedings of the National Academy of Sciences 111 (31), E3177-E3186, 2014
1612014
Crystal structures of NK1–heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor
D Lietha, DY Chirgadze, B Mulloy, TL Blundell, E Gherardi
The EMBO Journal 20 (20), 5543-5555, 2001
1392001
Structural and mechanistic insights into mechanoactivation of focal adhesion kinase
MS Bauer, F Baumann, C Daday, P Redondo, E Durner, MA Jobst, ...
Proceedings of the National Academy of Sciences 116 (14), 6766-6774, 2019
1282019
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation
D Lietha, MJ Eck
PloS one 3 (11), e3800, 2008
1222008
Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading
F Chang, C Lemmon, D Lietha, M Eck, L Romer
PloS one 6 (12), e28587, 2011
902011
The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay: elucidation of the …
M Lyon, JA Deakin, D Lietha, E Gherardi, JT Gallagher
Journal of Biological Chemistry 279 (42), 43560-43567, 2004
672004
Synthesis of novel diarylamino-1, 3, 5-triazine derivatives as FAK inhibitors with anti-angiogenic activity
P Dao, R Jarray, J Le Coq, D Lietha, A Loukaci, Y Lepelletier, ...
Bioorganic & medicinal chemistry letters 23 (16), 4552-4556, 2013
642013
Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity
P Dao, N Smith, C Tomkiewicz-Raulet, E Yen-Pon, M Camacho-Artacho, ...
Journal of medicinal chemistry 58 (1), 237-251, 2015
612015
Structural basis of Focal Adhesion Kinase activation on lipid membranes
I Acebrón, RD Righetto, C Schoenherr, S de Buhr, P Redondo, J Culley, ...
The EMBO journal 39 (19), e104743, 2020
592020
Allosteric regulation of focal adhesion kinase by PIP2 and ATP
J Zhou, A Bronowska, J Le Coq, D Lietha, F Gräter
Biophysical journal 108 (3), 698-705, 2015
562015
Roles of membrane domains in integrin-mediated cell adhesion
D Lietha, T Izard
International Journal of Molecular Sciences 21 (15), 5531, 2020
502020
A tethered ligand assay to probe SARS-CoV-2: ACE2 interactions
MS Bauer, S Gruber, A Hausch, PSFC Gomes, LF Milles, T Nicolaus, ...
Proceedings of the National Academy of Sciences 119 (14), e2114397119, 2022
482022
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange
K Takahashi, K Kanerva, L Vanharanta, L Almeida‐Souza, D Lietha, ...
The EMBO Journal 40 (14), e106871, 2021
482021
Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of antiangiogenic therapies
RA Toledo, E Garralda, M Mitsi, T Pons, J Monsech, E Vega, Á Otero, ...
Clinical Cancer Research 24 (15), 3550-3559, 2018
462018
Synthesis of novel 1, 2, 4-triazine scaffold as FAK inhibitors with antitumor activity
P Dao, D Lietha, M Etheve-Quelquejeu, C Garbay, H Chen
Bioorganic & Medicinal Chemistry Letters 27 (8), 1727-1730, 2017
452017
New insights into FAK structure and function in focal adhesions
J Le Coq, I Acebrón, B Rodrigo Martin, P López Navajas, D Lietha
Journal of Cell Science 135 (20), jcs259089, 2022
442022
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