Keiko Taguchi
Keiko Taguchi
The University of Tokyo
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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ...
Nature cell biology 12 (3), 213-223, 2010
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
K Taguchi, H Motohashi, M Yamamoto
Genes to cells 16 (2), 123-140, 2011
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
Y Mitsuishi, K Taguchi, Y Kawatani, T Shibata, T Nukiwa, H Aburatani, ...
Cancer cell 22 (1), 66-79, 2012
Keap1 degradation by autophagy for the maintenance of redox homeostasis
K Taguchi, N Fujikawa, M Komatsu, T Ishii, M Unno, T Akaike, ...
Proceedings of the National Academy of Sciences 109 (34), 13561-13566, 2012
The KEAP1–NRF2 system in cancer
K Taguchi, M Yamamoto
Frontiers in oncology 7, 85, 2017
Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles
Y Kumagai, S Koide, K Taguchi, A Endo, Y Nakai, T Yoshikawa, ...
Chemical research in toxicology 15 (4), 483-489, 2002
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
MS Yates, QT Tran, PM Dolan, WO Osburn, S Shin, CC McCulloch, ...
Carcinogenesis 30 (6), 1024-1031, 2009
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
T Saito, Y Ichimura, K Taguchi, T Suzuki, T Mizushima, K Takagi, Y Hirose, ...
Nature communications 7 (1), 12030, 2016
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
V Pekovic-Vaughan, J Gibbs, H Yoshitane, N Yang, D Pathiranage, B Guo, ...
Genes & development 28 (6), 548-560, 2014
Genetic analysis of cytoprotective functions supported by graded expression of Keap1
K Taguchi, JM Maher, T Suzuki, Y Kawatani, H Motohashi, M Yamamoto
Molecular and cellular biology 30 (12), 3016-3026, 2010
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
H Satoh, T Moriguchi, K Taguchi, J Takai, JM Maher, T Suzuki, ...
Carcinogenesis 31 (10), 1833-1843, 2010
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice
WO Osburn, MS Yates, PD Dolan, S Chen, KT Liby, MB Sporn, K Taguchi, ...
Toxicological Sciences 104 (1), 218-227, 2008
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate …
BE Riley, SE Kaiser, TA Shaler, ACY Ng, T Hara, MS Hipp, K Lage, ...
Journal of Cell Biology 191 (3), 537-552, 2010
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice
H Sugimoto, K Okada, J Shoda, E Warabi, K Ishige, T Ueda, K Taguchi, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology 298 (2 …, 2010
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice
K Okada, J Shoda, K Taguchi, JM Maher, K Ishizaki, Y Inoue, M Ohtsuki, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology 295 (4 …, 2008
Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity
T Toyama, D Sumi, Y Shinkai, A Yasutake, K Taguchi, KI Tong, ...
Biochemical and biophysical research communications 363 (3), 645-650, 2007
c‐erbB‐2 and c‐Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma
SI Aishima, KI Taguchi, K Sugimachi, M Shimada, K Sugimachi, ...
Histopathology 40 (3), 269-278, 2002
Critical role of Nrf2 in oxidative stress‐induced retinal ganglion cell death
N Himori, K Yamamoto, K Maruyama, M Ryu, K Taguchi, M Yamamoto, ...
Journal of neurochemistry 127 (5), 669-680, 2013
Primary hepatic carcinoid tumor: case report and review of 53 cases
M Iwao, M Nakamuta, M Enjoji, H Kubo, T Fukutomi, Y Tanabe, H Nishi, ...
Med Sci Monit 7 (4), 746-50, 2001
The KEAP1–NRF2 system as a molecular target of cancer treatment
K Taguchi, M Yamamoto
Cancers 13 (1), 46, 2020
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