| Toll-like receptors: from the discovery of NFκB to new insights into transcriptional regulations in innate immunity SL Doyle, LAJ O’Neill Biochemical pharmacology 72 (9), 1102-1113, 2006 | 813 | 2006 |
| Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation A Mansell, R Smith, SL Doyle, P Gray, JE Fenner, PJ Crack, SE Nicholson, ... Nature immunology 7 (2), 148-155, 2006 | 663 | 2006 |
| Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer LAJ O'Neill, CE Bryant, SL Doyle Pharmacological reviews 61 (2), 177-197, 2009 | 562 | 2009 |
| NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components SL Doyle, M Campbell, E Ozaki, RG Salomon, A Mori, PF Kenna, ... Nature medicine 18 (5), 791-798, 2012 | 465 | 2012 |
| Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives E Ozaki, M Campbell, SL Doyle Journal of inflammation research, 15-27, 2015 | 452 | 2015 |
| Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor κB activation by Toll-like receptor 4 CA Jefferies, S Doyle, C Brunner, A Dunne, E Brint, C Wietek, E Walch, ... Journal of Biological Chemistry 278 (28), 26258-26264, 2003 | 398 | 2003 |
| IL-10 inhibits miR-155 induction by toll-like receptors CE McCoy, FJ Sheedy, JE Qualls, SL Doyle, SR Quinn, PJ Murray, ... Journal of Biological Chemistry 285 (27), 20492-20498, 2010 | 339 | 2010 |
| MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction P Gray, A Dunne, C Brikos, CA Jefferies, SL Doyle, LAJ O'Neill Journal of Biological Chemistry 281 (15), 10489-10495, 2006 | 270 | 2006 |
| TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway EM Palsson-McDermott, SL Doyle, AF McGettrick, M Hardy, H Husebye, ... Nature immunology 10 (6), 579-586, 2009 | 221 | 2009 |
| IL-1 family cytokine regulation of vascular permeability and angiogenesis E Fahey, SL Doyle Frontiers in Immunology 10, 462450, 2019 | 200 | 2019 |
| Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFκB activation by lipopolysaccharide SL Doyle, CA Jefferies, LA O'Neill Journal of Biological Chemistry 280 (25), 23496-23501, 2005 | 171 | 2005 |
| Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase SL Doyle, CA Jefferies, C Feighery, LAJ O'Neill Journal of Biological Chemistry 282 (51), 36953-36960, 2007 | 152 | 2007 |
| IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration SL Doyle, E Ozaki, K Brennan, MM Humphries, K Mulfaul, J Keaney, ... Science translational medicine 6 (230), 230ra44-230ra44, 2014 | 120 | 2014 |
| TRAM is required for TLR2 endosomal signaling to type I IFN induction J Stack, SL Doyle, DJ Connolly, LS Reinert, KM O’Keeffe, RM McLoughlin, ... The Journal of Immunology 193 (12), 6090-6102, 2014 | 116 | 2014 |
| NLRP3 inflammasome and pathobiology in AMD L Celkova, SL Doyle, M Campbell Journal of clinical medicine 4 (1), 172-192, 2015 | 98 | 2015 |
| The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation SL Doyle, H Husebye, DJ Connolly, T Espevik, LA O'neill, AF McGettrick Nature Communications 3 (1), 707, 2012 | 69 | 2012 |
| Bruton’s tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin EF Kenny, SR Quinn, SL Doyle, PM Vink, H van Eenennaam, LAJ O’Neill PloS one 8 (8), e74103, 2013 | 66 | 2013 |
| Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor H Yuan, CM Wilson, J Xia, SL Doyle, S Li, AM Fales, Y Liu, E Ozaki, ... Nanoscale 6 (8), 4078-4082, 2014 | 62 | 2014 |
| Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction E Giannoudaki, YE Hernandez-Santana, K Mulfaul, SL Doyle, E Hams, ... Nature communications 10 (1), 4003, 2019 | 56 | 2019 |
| Interleukin‐33 regulates tissue remodelling and inhibits angiogenesis in the eye S Theodoropoulou, DA Copland, J Liu, J Wu, PJ Gardner, E Ozaki, ... The Journal of pathology 241 (1), 45-56, 2017 | 55 | 2017 |
Caroline JefferiesAssociate Professor, Cedars Sinai Medical CenterBestätigte E-Mail-Adresse bei cshs.org
