Motohashi Hozumi
Motohashi Hozumi
Institute of Development, Aging and Cancer, Tohoku University
Verified email at - Homepage
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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ...
Nature cell biology 12 (3), 213-223, 2010
Nrf2–Keap1 defines a physiologically important stress response mechanism
H Motohashi, M Yamamoto
Trends in molecular medicine 10 (11), 549-557, 2004
A promoter-level mammalian expression atlas
Nature 507 (7493), 462-470, 2014
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
K Taguchi, H Motohashi, M Yamamoto
Genes to cells 16 (2), 123-140, 2011
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
EH Kobayashi, T Suzuki, R Funayama, T Nagashima, M Hayashi, ...
Nature communications 7 (1), 1-14, 2016
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
Y Mitsuishi, K Taguchi, Y Kawatani, T Shibata, T Nukiwa, H Aburatani, ...
Cancer cell 22 (1), 66-79, 2012
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
M Yamamoto, TW Kensler, H Motohashi
Physiological reviews 98 (3), 1169-1203, 2018
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
Y Ichimura, S Waguri, Y Sou, S Kageyama, J Hasegawa, R Ishimura, ...
Molecular cell 51 (5), 618-631, 2013
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
N Wakabayashi, K Itoh, J Wakabayashi, H Motohashi, S Noda, ...
Nature genetics 35 (3), 238-245, 2003
Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling
T Ida, T Sawa, H Ihara, Y Tsuchiya, Y Watanabe, Y Kumagai, M Suematsu, ...
Proceedings of the National Academy of Sciences 111 (21), 7606-7611, 2014
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: identification of novel gene clusters for cell survival
MK Kwak, N Wakabayashi, K Itoh, H Motohashi, M Yamamoto, ...
Journal of Biological Chemistry 278 (10), 8135-8145, 2003
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
T Oyake, K Itoh, H Motohashi, N Hayashi, H Hoshino, M Nishizawa, ...
Molecular and cellular biology 16 (11), 6083-6095, 1996
Toward clinical application of the Keap1–Nrf2 pathway
T Suzuki, H Motohashi, M Yamamoto
Trends in pharmacological sciences 34 (6), 340-346, 2013
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
T Yamamoto, T Suzuki, A Kobayashi, J Wakabayashi, J Maher, ...
Molecular and cellular biology 28 (8), 2758-2770, 2008
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors
H Motohashi, T O'Connor, F Katsuoka, JD Engel, M Yamamoto
Gene 294 (1-2), 1-12, 2002
Keap1 degradation by autophagy for the maintenance of redox homeostasis
K Taguchi, N Fujikawa, M Komatsu, T Ishii, M Unno, T Akaike, ...
Proceedings of the National Academy of Sciences 109 (34), 13561-13566, 2012
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
H Okawa, H Motohashi, A Kobayashi, H Aburatani, TW Kensler, ...
Biochemical and biophysical research communications 339 (1), 79-88, 2006
The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism
Y Mitsuishi, H Motohashi, M Yamamoto
Frontiers in oncology 2, 200, 2012
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
T Akaike, T Ida, FY Wei, M Nishida, Y Kumagai, MM Alam, H Ihara, ...
Nature communications 8 (1), 1177, 2017
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway
H Motohashi, F Katsuoka, JD Engel, M Yamamoto
Proceedings of the National Academy of Sciences 101 (17), 6379-6384, 2004
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