Ashwani Kumar Thakur
Ashwani Kumar Thakur
Biological Sciences and Bioengineering Department, Indian Institute of Technology, Kanpur UP-India
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Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism
AK Thakur, M Jayaraman, R Mishra, M Thakur, VM Chellgren, IJ L Byeon, ...
Nature structural & molecular biology 16 (4), 380-389, 2009
Oligoproline effects on polyglutamine conformation and aggregation
A Bhattacharyya, AK Thakur, VM Chellgren, G Thiagarajan, AD Williams, ...
Journal of molecular biology 355 (3), 524-535, 2006
Mutational analysis of the structural organization of polyglutamine aggregates
AK Thakur, R Wetzel
Proceedings of the National Academy of Sciences 99 (26), 17014-17019, 2002
The toxicological mechanisms of environmental soot (black carbon) and carbon black: focus on oxidative stress and inflammatory pathways
R Niranjan, AK Thakur
Frontiers in immunology 8, 763, 2017
Polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction
AM Bhattacharyya, AK Thakur, R Wetzel
Proceedings of the National Academy of Sciences 102 (43), 15400-15405, 2005
Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments
M Jayaraman, R Kodali, B Sahoo, AK Thakur, A Mayasundari, R Mishra, ...
Journal of molecular biology 415 (5), 881-899, 2012
Kinetics and thermodynamics of amyloid assembly using a high‐performance liquid chromatography–based sedimentation assay
B O'Nuallain, AK Thakur, AD Williams, AM Bhattacharyya, S Chen, ...
Methods in enzymology 413, 34-74, 2006
Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria
V Singh, RK Rai, A Arora, N Sinha, AK Thakur
Scientific reports 4 (1), 1-8, 2014
Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates
R Mishra, M Jayaraman, BP Roland, E Landrum, T Fullam, R Kodali, ...
Journal of molecular biology 415 (5), 900-917, 2012
Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties
M Jayaraman, R Mishra, R Kodali, AK Thakur, LMI Koharudin, ...
Biochemistry 51 (13), 2706-2716, 2012
Understanding the self-assembly of Fmoc–phenylalanine to hydrogel formation
V Singh, K Snigdha, C Singh, N Sinha, AK Thakur
Soft Matter 11 (26), 5353-5364, 2015
In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence
Z Ignatova, AK Thakur, R Wetzel, LM Gierasch
Journal of Biological Chemistry 282 (50), 36736-36743, 2007
CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity
M Arango, S Holbert, D Zala, E Brouillet, J Pearson, E Régulier, ...
Journal of Neuroscience 26 (17), 4649-4659, 2006
Fmoc-phenylalanine displays antibacterial activity against Gram-positive bacteria in gel and solution phases
AY Gahane, P Ranjan, V Singh, RK Sharma, N Sinha, M Sharma, ...
Soft matter 14 (12), 2234-2244, 2018
Inhibition of polyglutamine aggregate cytotoxicity by a structure‐based elongation inhibitor
AK Thakur, W Yang, R Wetzel
The FASEB journal 18 (7), 923-925, 2004
Assays for studying nucleated aggregation of polyglutamine proteins
M Jayaraman, AK Thakur, K Kar, R Kodali, R Wetzel
Methods 53 (3), 246-254, 2011
Inhibition of cyclooxygenase-2 (COX-2) initiates autophagy and potentiates MPTP-induced autophagic cell death of human neuroblastoma cells, SH-SY5Y: an inside in the pathology …
R Niranjan, KP Mishra, AK Thakur
Molecular neurobiology 55 (10), 8038-8050, 2018
Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux
A Rai, PK Singh, V Singh, V Kumar, R Mishra, AK Thakur, A Mahadevan, ...
Cell death & disease 9 (2), 1-15, 2018
Stabilization of a novel β‐turn‐like motif by nonconventional intramolecular hydrogen‐bonding interactions in a model peptide incorporating β‐alanine
AK Thakur, R Kishore
Biopolymers: Original Research on Biomolecules 53 (6), 447-454, 2000
N‐terminal domain of Pyrococcus furiosus l‐asparaginase functions as a non‐specific, stable, molecular chaperone
R Tomar, DK Garg, R Mishra, AK Thakur, B Kundu
The FEBS journal 280 (11), 2688-2699, 2013
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