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Roles of proximal ligand in heme proteins: replacement of proximal histidine of human myoglobin with cysteine and tyrosine by site-directed mutagenesis as models for P-450 …
S Adachi, S Nagano, K Ishimori, Y Watanabe, I Morishima, T Egawa, ...
Biochemistry 32 (1), 241-252, 1993
Conformational landscape of cytochrome c folding studied by microsecond-resolved small-angle x-ray scattering
S Akiyama, S Takahashi, T Kimura, K Ishimori, I Morishima, Y Nishikawa, ...
Proceedings of the National Academy of Sciences 99 (3), 1329-1334, 2002
Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2
K Yamanaka, H Ishikawa, Y Megumi, F Tokunaga, M Kanie, TA Rouault, ...
Nature cell biology 5 (4), 336-340, 2003
Stepwise formation of α-helices during cytochrome c folding
S Akiyama, S Takahashi, K Ishimori, I Morishima
Nature structural biology 7 (6), 514-520, 2000
Collapse and search dynamics of apomyoglobin folding revealed by submillisecond observations of α-helical content and compactness
T Uzawa, S Akiyama, T Kimura, S Takahashi, K Ishimori, I Morishima, ...
Proceedings of the National Academy of Sciences 101 (5), 1171-1176, 2004
Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2
H Ishikawa, M Kato, H Hori, K Ishimori, T Kirisako, F Tokunaga, K Iwai
Molecular cell 19 (2), 171-181, 2005
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
Y Kabe, T Nakane, I Koike, T Yamamoto, Y Sugiura, E Harada, K Sugase, ...
Nature communications 7 (1), 1-13, 2016
Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site
S Yoshioka, S Takahashi, K Ishimori, I Morishima
Journal of inorganic biochemistry 81 (3), 141-151, 2000
Roles of the Proximal Hydrogen Bonding Network in Cytochrome P450cam-Catalyzed Oxygenation
S Yoshioka, T Tosha, S Takahashi, K Ishimori, H Hori, I Morishima
Journal of the American Chemical Society 124 (49), 14571-14579, 2002
Catalytic Roles of the Distal Site Asparagine− Histidine Couple in Peroxidases
S Nagano, M Tanaka, K Ishimori, Y Watanabe, I Morishima
Biochemistry 35 (45), 14251-14258, 1996
Two heme binding sites are involved in the regulated degradation of the bacterial iron response regulator (Irr) protein
J Yang, K Ishimori, MR O'Brian
Journal of Biological Chemistry 280 (9), 7671-7676, 2005
Specific collapse followed by slow hydrogen-bond formation of β-sheet in the folding of single-chain monellin
T Kimura, T Uzawa, K Ishimori, I Morishima, S Takahashi, T Konno, ...
Proceedings of the National Academy of Sciences 102 (8), 2748-2753, 2005
Catalytic activities and structural properties of horseradish peroxidase distal His42→ Glu or Gln mutant
M Tanaka, K Ishimori, M Mukai, T Kitagawa, I Morishima
Biochemistry 36 (32), 9889-9898, 1997
Alteration of human myoglobin proximal histidine to cysteine or tyrosine by site-directed mutagenesis: characterization and their catalytic activities
S Adachi, S Nagano, Y Watanabe, K Ishimori, I Morishima
Biochemical and biophysical research communications 180 (1), 138-144, 1991
Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR
T Uzawa, C Nishimura, S Akiyama, K Ishimori, S Takahashi, HJ Dyson, ...
Proceedings of the National Academy of Sciences 105 (37), 13859-13864, 2008
Effects of concerted hydrogen bonding of distal histidine on active site structures of horseradish peroxidase. Resonance Raman studies with Asn70 mutants
M Mukai, S Nagano, M Tanaka, K Ishimori, I Morishima, T Ogura, ...
Journal of the American Chemical Society 119 (7), 1758-1766, 1997
Direct electron transfer catalysed by recombinant forms of horseradish peroxidase: insight into the mechanism
A Lindgren, M Tanaka, T Ruzgas, L Gorton, I Gazaryan, K Ishimori, ...
Electrochemistry communications 1 (5), 171-175, 1999
Preparation and reactions of myoglobin mutants bearing both proximal cysteine ligand and hydrophobic distal cavity: protein models for the active site of P-450
T Matsui, S Nagano, K Ishimori, Y Watanabe, I Morishima
Biochemistry 35 (40), 13118-13124, 1996
Identification of histidine 77 as the axial heme ligand of carbonmonoxy CooA by picosecond time-resolved resonance Raman spectroscopy
T Uchida, H Ishikawa, K Ishimori, I Morishima, H Nakajima, S Aono, ...
Biochemistry 39 (42), 12747-12752, 2000
Proximal cysteine residue is essential for the enzymatic activities of cytochrome P450cam
S Yoshioka, S Takahashi, H Hori, K Ishimori, I Morishima
European Journal of Biochemistry 268 (2), 252-259, 2001
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