| Roles of proximal ligand in heme proteins: replacement of proximal histidine of human myoglobin with cysteine and tyrosine by site-directed mutagenesis as models for P-450 … S Adachi, S Nagano, K Ishimori, Y Watanabe, I Morishima, T Egawa, ... Biochemistry 32 (1), 241-252, 1993 | 328 | 1993 |
| Conformational landscape of cytochrome c folding studied by microsecond-resolved small-angle x-ray scattering S Akiyama, S Takahashi, T Kimura, K Ishimori, I Morishima, Y Nishikawa, ... Proceedings of the National Academy of Sciences 99 (3), 1329-1334, 2002 | 308 | 2002 |
| Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2 K Yamanaka, H Ishikawa, Y Megumi, F Tokunaga, M Kanie, TA Rouault, ... Nature cell biology 5 (4), 336-340, 2003 | 222 | 2003 |
| Stepwise formation of α-helices during cytochrome c folding S Akiyama, S Takahashi, K Ishimori, I Morishima Nature structural biology 7 (6), 514-520, 2000 | 205 | 2000 |
| Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance Y Kabe, T Nakane, I Koike, T Yamamoto, Y Sugiura, E Harada, K Sugase, ... Nature communications 7 (1), 11030, 2016 | 191 | 2016 |
| Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2 H Ishikawa, M Kato, H Hori, K Ishimori, T Kirisako, F Tokunaga, K Iwai Molecular cell 19 (2), 171-181, 2005 | 188 | 2005 |
| Collapse and search dynamics of apomyoglobin folding revealed by submillisecond observations of α-helical content and compactness T Uzawa, S Akiyama, T Kimura, S Takahashi, K Ishimori, I Morishima, ... Proceedings of the National Academy of Sciences 101 (5), 1171-1176, 2004 | 176 | 2004 |
| Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site S Yoshioka, S Takahashi, K Ishimori, I Morishima Journal of inorganic biochemistry 81 (3), 141-151, 2000 | 139 | 2000 |
| Roles of the Proximal Hydrogen Bonding Network in Cytochrome P450cam-Catalyzed Oxygenation S Yoshioka, T Tosha, S Takahashi, K Ishimori, H Hori, I Morishima Journal of the American Chemical Society 124 (49), 14571-14579, 2002 | 126 | 2002 |
| Two heme binding sites are involved in the regulated degradation of the bacterial iron response regulator (Irr) protein J Yang, K Ishimori, MR O'Brian Journal of Biological Chemistry 280 (9), 7671-7676, 2005 | 112 | 2005 |
| Catalytic Roles of the Distal Site Asparagine− Histidine Couple in Peroxidases S Nagano, M Tanaka, K Ishimori, Y Watanabe, I Morishima Biochemistry 35 (45), 14251-14258, 1996 | 110 | 1996 |
| Specific collapse followed by slow hydrogen-bond formation of β-sheet in the folding of single-chain monellin T Kimura, T Uzawa, K Ishimori, I Morishima, S Takahashi, T Konno, ... Proceedings of the National Academy of Sciences 102 (8), 2748-2753, 2005 | 104 | 2005 |
| Alteration of human myoglobin proximal histidine to cysteine or tyrosine by site-directed mutagenesis: characterization and their catalytic activities S Adachi, S Nagano, Y Watanabe, K Ishimori, I Morishima Biochemical and biophysical research communications 180 (1), 138-144, 1991 | 103 | 1991 |
| Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR T Uzawa, C Nishimura, S Akiyama, K Ishimori, S Takahashi, HJ Dyson, ... Proceedings of the National Academy of Sciences 105 (37), 13859-13864, 2008 | 98 | 2008 |
| Effects of concerted hydrogen bonding of distal histidine on active site structures of horseradish peroxidase. Resonance Raman studies with Asn70 mutants M Mukai, S Nagano, M Tanaka, K Ishimori, I Morishima, T Ogura, ... Journal of the American Chemical Society 119 (7), 1758-1766, 1997 | 94 | 1997 |
| Catalytic activities and structural properties of horseradish peroxidase distal His42→ Glu or Gln mutant M Tanaka, K Ishimori, M Mukai, T Kitagawa, I Morishima Biochemistry 36 (32), 9889-9898, 1997 | 93 | 1997 |
| Direct electron transfer catalysed by recombinant forms of horseradish peroxidase: insight into the mechanism A Lindgren, M Tanaka, T Ruzgas, L Gorton, I Gazaryan, K Ishimori, ... Electrochemistry Communications 1 (5), 171-175, 1999 | 92 | 1999 |
| Preparation and reactions of myoglobin mutants bearing both proximal cysteine ligand and hydrophobic distal cavity: protein models for the active site of P-450 T Matsui, S Nagano, K Ishimori, Y Watanabe, I Morishima Biochemistry 35 (40), 13118-13124, 1996 | 84 | 1996 |
| Proximal cysteine residue is essential for the enzymatic activities of cytochrome P450cam S Yoshioka, S Takahashi, H Hori, K Ishimori, I Morishima European Journal of Biochemistry 268 (2), 252-259, 2001 | 83 | 2001 |
| Identification of histidine 77 as the axial heme ligand of carbonmonoxy CooA by picosecond time-resolved resonance Raman spectroscopy T Uchida, H Ishikawa, K Ishimori, I Morishima, H Nakajima, S Aono, ... Biochemistry 39 (42), 12747-12752, 2000 | 82 | 2000 |
