In vivo–directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous D Dalkara, LC Byrne, RR Klimczak, M Visel, L Yin, WH Merigan, ... Science translational medicine 5 (189), 189ra76-189ra76, 2013 | 794 | 2013 |
Activation of specific interneurons improves V1 feature selectivity and visual perception SH Lee, AC Kwan, S Zhang, V Phoumthipphavong, JG Flannery, ... Nature 488 (7411), 379-383, 2012 | 660 | 2012 |
Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa AS Lewin, KA Drenser, WW Hauswirth, S Nishikawa, D Yasumura, ... Nature medicine 4 (8), 967-971, 1998 | 519 | 1998 |
Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus JG Flannery, S Zolotukhin, MI Vaquero, MM LaVail, N Muzyczka, ... Proceedings of the National Academy of Sciences 94 (13), 6916-6921, 1997 | 511 | 1997 |
Remote control of neuronal activity with a light-gated glutamate receptor S Szobota, P Gorostiza, F Del Bene, C Wyart, DL Fortin, KD Kolstad, ... Neuron 54 (4), 535-545, 2007 | 398 | 2007 |
Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous D Dalkara, KD Kolstad, N Caporale, M Visel, RR Klimczak, DV Schaffer, ... Molecular Therapy 17 (12), 2096-2102, 2009 | 384 | 2009 |
bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. J Chen, JG Flannery, MM LaVail, RH Steinberg, J Xu, MI Simon Proceedings of the National Academy of Sciences 93 (14), 7042-7047, 1996 | 300 | 1996 |
Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy MM LaVail, D Yasumura, MT Matthes, KA Drenser, JG Flannery, AS Lewin, ... Proceedings of the National Academy of Sciences 97 (21), 11488-11493, 2000 | 266 | 2000 |
A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells RR Klimczak, JT Koerber, D Dalkara, JG Flannery, DV Schaffer PloS one 4 (10), e7467, 2009 | 247 | 2009 |
Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa LHMG Sanftner, H Abel, WW Hauswirth, JG Flannery Molecular Therapy 4 (6), 622-629, 2001 | 246 | 2001 |
Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2 D Lau, LH McGee, S Zhou, KG Rendahl, WC Manning, JA Escobedo, ... Investigative ophthalmology & visual science 41 (11), 3622-3633, 2000 | 234 | 2000 |
Molecular evolution of adeno-associated virus for enhanced glial gene delivery JT Koerber, R Klimczak, JH Jang, D Dalkara, JG Flannery, DV Schaffer Molecular Therapy 17 (12), 2088-2095, 2009 | 219 | 2009 |
Intravitreal injection of AAV2 transduces macaque inner retina L Yin, K Greenberg, JJ Hunter, D Dalkara, KD Kolstad, BD Masella, ... Investigative ophthalmology & visual science 52 (5), 2775-2783, 2011 | 218 | 2011 |
Looking within for vision JG Flannery, KP Greenberg Neuron 50 (1), 1-3, 2006 | 208 | 2006 |
Inherited retinal degenerations: current landscape and knowledge gaps JL Duncan, EA Pierce, AM Laster, SP Daiger, DG Birch, JD Ash, ... Translational vision science & technology 7 (4), 6-6, 2018 | 202 | 2018 |
LiGluR restores visual responses in rodent models of inherited blindness N Caporale, KD Kolstad, T Lee, I Tochitsky, D Dalkara, D Trauner, ... Molecular therapy 19 (7), 1212-1219, 2011 | 202 | 2011 |
The rd mouse story: seventy years of research on an animal model of inherited retinal degeneration DB Farber, JG Flannery, C Bowes-Rickman Progress in retinal and eye research 13 (1), 31-64, 1994 | 201 | 1994 |
USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses A Adato, S Vreugde, T Joensuu, N Avidan, R Hamalainen, O Belenkiy, ... European Journal of Human Genetics 10 (6), 339-350, 2002 | 200 | 2002 |
Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice J Lem, ML Applebury, JD Falk, JG Flannery, MI Simon Neuron 6 (2), 201-210, 1991 | 197 | 1991 |
The occurrence of serum autoantibodies against enolase in cancer-associated retinopathy G Adamus, N Aptsiauri, J Guy, J Heckenlively, J Flannery, PA Hargrave Clinical immunology and immunopathology 78 (2), 120-129, 1996 | 196 | 1996 |