PI in SYSUCC and Senior Scientist in NCCS
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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
J Tan, X Yang, L Zhuang, X Jiang, W Chen, PL Lee, RKM Karuturi, ...
Genes & development 21 (9), 1050-1063, 2007
Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma
A Jusakul, I Cutcutache, CH Yong, JQ Lim, MN Huang, N Padmanabhan, ...
Cancer discovery 7 (10), 1116-1135, 2017
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
Y Zhao, J Tan, L Zhuang, X Jiang, ET Liu, Q Yu
Proceedings of the National Academy of Sciences 102 (44), 16090-16095, 2005
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
TL Song, ML Nairismägi, Y Laurensia, JQ Lim, J Tan, ZM Li, WL Pang, ...
Blood, The Journal of the American Society of Hematology 132 (11), 1146-1158, 2018
DACT3 is an epigenetic regulator of Wnt/β-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications
X Jiang, J Tan, J Li, S Kivimäe, X Yang, L Zhuang, PL Lee, MTW Chan, ...
Cancer cell 13 (6), 529-541, 2008
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma
WK Lim, CK Ong, J Tan, AA Thike, CCY Ng, V Rajasegaran, SS Myint, ...
Nature genetics 46 (8), 877-880, 2014
Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes
R Xue, LU Chen, C Zhang, M Fujita, R Li, SM Yan, CK Ong, X Liao, Q Gao, ...
Cancer cell 35 (6), 932-947. e8, 2019
Genomic landscapes of breast fibroepithelial tumors
J Tan, CK Ong, WK Lim, CCY Ng, AA Thike, LM Ng, V Rajasegaran, ...
Nature genetics 47 (11), 1341-1345, 2015
The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor …
TJ Seng, JSW Low, H Li, Y Cui, HK Goh, MLY Wong, G Srivastava, ...
Oncogene 26 (6), 934-944, 2007
PDK1 signaling toward PLK1–MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy
J Tan, Z Li, PL Lee, P Guan, MY Aau, ST Lee, M Feng, CZ Lim, EYJ Lee, ...
Cancer discovery 3 (10), 1156-1171, 2013
Pharmacologic modulation of glycogen synthase kinase-3β promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells
J Tan, L Zhuang, HS Leong, NG Iyer, ET Liu, Q Yu
Cancer research 65 (19), 9012-9020, 2005
JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma
ML Nairismägi, J Tan, JQ Lim, S Nagarajan, CCY Ng, V Rajasegaran, ...
Leukemia 30 (6), 1311-1319, 2016
B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer
J Tan, PL Lee, Z Li, X Jiang, YC Lim, SC Hooi, Q Yu
Cancer cell 18 (5), 459-471, 2010
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
X Yao, J Tan, KJ Lim, J Koh, WF Ooi, Z Li, D Huang, M Xing, YS Chan, ...
Cancer discovery 7 (11), 1284-1305, 2017
The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas
L Li, J Ying, H Li, Y Zhang, X Shu, Y Fan, J Tan, Y Cao, SW Tsao, ...
Oncogene 31 (34), 3901-3912, 2012
Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage
Z Wu, ST Lee, Y Qiao, Z Li, PL Lee, YJ Lee, X Jiang, J Tan, M Aau, ...
Cell Death & Differentiation 18 (11), 1771-1779, 2011
Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitorinduced apoptosis through positive feedback regulation of E2F1 …
J Tan, L Zhuang, X Jiang, KK Yang, KM Karuturi, Q Yu
Journal of Biological Chemistry 281 (15), 10508-10515, 2006
MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases
CCY Ng, J Tan, CK Ong, WK Lim, V Rajasegaran, NDM Nasir, JCT Lim, ...
Journal of clinical pathology 68 (9), 685-691, 2015
Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress
J Li, J Tan, L Zhuang, B Banerjee, X Yang, JFL Chau, PL Lee, MP Hande, ...
Cancer Research 67 (23), 11317-11326, 2007
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma
JY Chan, JQ Lim, J Yeong, V Ravi, P Guan, A Boot, TKY Tay, ...
The Journal of clinical investigation 130 (11), 5833-5846, 2020
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