Andrew Hedman
Andrew Hedman
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The biology of IQGAP proteins: beyond the cytoskeleton
AC Hedman, JM Smith, DB Sacks
EMBO reports 16 (4), 427-446, 2015
IQGAPs choreograph cellular signaling from the membrane to the nucleus
JM Smith, AC Hedman, DB Sacks
Trends in cell biology 25 (3), 171-184, 2015
Phosphatidylinositol 4, 5‐bisphosphate: Targeted production and signaling
Y Sun, N Thapa, AC Hedman, RA Anderson
Bioessays 35 (6), 513-522, 2013
Agonist-stimulated phosphatidylinositol-3, 4, 5-trisphosphate generation by scaffolded phosphoinositide kinases
S Choi, AC Hedman, S Sayedyahossein, N Thapa, DB Sacks, ...
Nature Cell Biology 18 (12), 1324-1335, 2016
Endosomal type Iγ PIP 5-kinase controls EGF receptor lysosomal sorting
Y Sun, AC Hedman, X Tan, NJ Schill, RA Anderson
Developmental cell 25 (2), 144-155, 2013
PIP kinases define PI4, 5P 2 signaling specificity by association with effectors
S Choi, N Thapa, X Tan, AC Hedman, RA Anderson
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2015
IQGAP1 is a novel phosphatidylinositol 4, 5 bisphosphate effector in regulation of directional cell migration
S Choi, N Thapa, AC Hedman, Z Li, DB Sacks, RA Anderson
The EMBO journal 32 (19), 2617-2630, 2013
LAPTM4B is a PtdIns (4, 5) P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation
X Tan, Y Sun, N Thapa, Y Liao, AC Hedman, RA Anderson
The EMBO journal 34 (4), 475-490, 2015
IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity
S Sayedyahossein, Z Li, AC Hedman, CJ Morgan, DB Sacks
Journal of Biological Chemistry 291 (37), 19261-19273, 2016
PIP Kinases from the Cell Membrane to the Nucleus
M Schramp, A Hedman, W Li, X Tan, R Anderson
Phosphoinositides I: Enzymes of Synthesis and Degradation, 25-59, 2012
Isoform 5 of PIPKIγ regulates the endosomal trafficking and degradation of E-cadherin
NJ Schill, AC Hedman, S Choi, RA Anderson
Journal of cell science 127 (10), 2189-2203, 2014
Absence of IQGAP1 Protein Leads to Insulin Resistance
B Chawla, AC Hedman, S Sayedyahossein, HH Erdemir, Z Li, DB Sacks
Journal of Biological Chemistry 292 (8), 3273-3289, 2017
Calmodulin Lobes Facilitate Dimerization and Activation of Estrogen Receptor-α
Z Li, Y Zhang, AC Hedman, JB Ames, DB Sacks
Journal of Biological Chemistry 292 (11), 4614-4622, 2017
Phosphatidylinositol Phosphate 5-Kinase Iγi2 in Association with Src Controls Anchorage-independent Growth of Tumor Cells
N Thapa, S Choi, A Hedman, X Tan, RA Anderson
Journal of Biological Chemistry 288 (48), 34707-34718, 2013
Ca2+-Dependent Switch of Calmodulin Interaction Mode with Tandem IQ Motifs in the Scaffolding Protein IQGAP1
M Zhang, Z Li, H Jang, AC Hedman, DB Sacks, R Nussinov
Biochemistry 58 (49), 4903-4911, 2019
Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras
CJ Morgan, AC Hedman, Z Li, DB Sacks
Scientific Reports 9 (1), 11057, 2019
IQGAP1 binds AMPK and is required for maximum AMPK activation
AC Hedman, Z Li, L Gorisse, S Parvathaneni, CJ Morgan, DB Sacks
Journal of Biological Chemistry 296, 2021
Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42
L Gorisse, Z Li, CD Wagner, DK Worthylake, F Zappacosta, AC Hedman, ...
Journal of Biological Chemistry 295 (15), 4822-4835, 2020
An unexpected role for PI4, 5P2 in EGF receptor endosomal trafficking
Y Sun, AC Hedman, X Tan, RA Anderson
Cell Cycle 12 (13), 1991-1992, 2013
IQGAP1 binds the Axl receptor kinase and inhibits its signaling
L Gorisse, Z Li, AC Hedman, DB Sacks
Biochemical Journal 475 (19), 3073-3086, 2018
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