Roxana Iacob
Roxana Iacob
Research Associate Professor, Northeastern University
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Cited by
Cited by
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
W Zhou, D Ercan, L Chen, CH Yun, D Li, M Capelletti, AB Cortot, ...
Nature 462 (7276), 1070-1074, 2009
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ...
Nature 463 (7280), 501-506, 2010
Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis
J McLaurin, R Cecal, ME Kierstead, X Tian, AL Phinney, M Manea, ...
Nature medicine 8 (11), 1263-1269, 2002
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ...
Nature communications 3 (1), 1-12, 2012
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ...
Nature methods 16 (7), 595-602, 2019
Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications
H Wei, J Mo, L Tao, RJ Russell, AA Tymiak, G Chen, RE Iacob, JR Engen
Drug discovery today 19 (1), 95-102, 2014
Force interacts with macromolecular structure in activation of TGF-β
X Dong, B Zhao, RE Iacob, J Zhu, AC Koksal, C Lu, JR Engen, ...
Nature 542 (7639), 55-59, 2017
Applications of hydrogen/deuterium exchange MS from 2012 to 2014
GF Pirrone, RE Iacob, JR Engen
Analytical chemistry 87 (1), 99-118, 2015
Hydrogen exchange mass spectrometry: are we out of the quicksand?
RE Iacob, JR Engen
Journal of the American Society for Mass Spectrometry 23 (6), 1003-1010, 2012
Structure and dynamic regulation of Abl kinases
S Panjarian, RE Iacob, S Chen, JR Engen, TE Smithgall
Journal of Biological Chemistry 288 (8), 5443-5450, 2013
Structure-guided development of a potent and selective non-covalent active-site inhibitor of USP7
I Lamberto, X Liu, HS Seo, NJ Schauer, RE Iacob, W Hu, D Das, ...
Cell chemical biology 24 (12), 1490-1500. e11, 2017
Conformational disturbance in Abl kinase upon mutation and deregulation
RE Iacob, T Pene-Dumitrescu, J Zhang, NS Gray, TE Smithgall, JR Engen
Proceedings of the National Academy of Sciences 106 (5), 1386-1391, 2009
Functionalized magnetic micro‐and nanoparticles: Optimization and application to μ‐chip tryptic digestion
Z Bílková, M Slováková, N Minc, C Fütterer, R Cecal, D Horák, M Beneš, ...
Electrophoresis 27 (9), 1811-1824, 2006
Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements
RE Iacob, GM Bou-Assaf, L Makowski, JR Engen, SA Berkowitz, D Houde
Journal of pharmaceutical sciences 102 (12), 4315-4329, 2013
Mass spectrometric characterization of glycosylation of hepatitis C virus E2 envelope glycoprotein reveals extended microheterogeneity of N-glycans
RE Iacob, I Perdivara, M Przybylski, KB Tomer
Journal of the American Society for Mass Spectrometry 19 (3), 428-444, 2011
Ion mobility adds an additional dimension to mass spectrometric analysis of solution‐phase hydrogen/deuterium exchange
RE Iacob, JP Murphy III, JR Engen
Rapid Communications in Mass Spectrometry 22 (18), 2898-2904, 2008
Tissue-specific oncogenic activity of KRASA146T
EJ Poulin, AK Bera, J Lu, YJ Lin, SD Strasser, JA Paulo, TQ Huang, ...
Cancer discovery 9 (6), 738-755, 2019
Chemically induced degradation of the oncogenic transcription factor BCL6
N Kerres, S Steurer, S Schlager, G Bader, H Berger, M Caligiuri, C Dank, ...
Cell reports 20 (12), 2860-2875, 2017
Mass Spectrometric Approaches for Elucidation of Antigen—Antibody Recognition Structures in Molecular Immunology
R Stefanescu, RE Iacob, EN Damoc, A Marquardt, E Amstalden, M Manea, ...
European Journal of Mass Spectrometry 13 (1), 69-75, 2007
Allosteric interactions between the myristate-and ATP-site of the Abl kinase
RE Iacob, J Zhang, NS Gray, JR Engen
PloS one 6 (1), e15929, 2011
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