| Exploring targeted degradation strategy for oncogenic KRASG12C M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ... Cell chemical biology 27 (1), 19-31. e6, 2020 | 209 | 2020 |
| Potent and selective covalent quinazoline inhibitors of KRAS G12C M Zeng, J Lu, L Li, F Feru, C Quan, TW Gero, SB Ficarro, Y Xiong, ... Cell chemical biology 24 (8), 1005-1016. e3, 2017 | 138 | 2017 |
| Targeted protein degradation as a powerful research tool in basic biology and drug target discovery T Wu, H Yoon, Y Xiong, SE Dixon-Clarke, RP Nowak, ES Fischer Nature Structural & Molecular Biology 27 (7), 605-614, 2020 | 131 | 2020 |
| Covalent guanosine mimetic inhibitors of G12C KRAS Y Xiong, J Lu, J Hunter, L Li, D Scott, HG Choi, SM Lim, A Manandhar, ... ACS medicinal chemistry letters 8 (1), 61-66, 2017 | 76 | 2017 |
| Asymmetric syntheses of the flavonoid Diels–Alder natural products sanggenons C and O C Qi, Y Xiong, V Eschenbrenner-Lux, H Cong, JA Porco Jr Journal of the American Chemical Society 138 (3), 798-801, 2016 | 58 | 2016 |
| Chemo-proteomics exploration of HDAC degradability by small molecule degraders Y Xiong, KA Donovan, NA Eleuteri, N Kirmani, H Yue, A Razov, ... Cell chemical biology 28 (10), 1514-1527. e4, 2021 | 46 | 2021 |
| Enantioselective synthesis of 3, 4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones JC Marié, Y Xiong, GK Min, AR Yeager, T Taniguchi, N Berova, ... The Journal of organic chemistry 75 (13), 4584-4590, 2010 | 39 | 2010 |
| Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers Y Xiong, SE Schaus, JA Porco Jr Organic letters 15 (8), 1962-1965, 2013 | 24 | 2013 |
| Structure-guided design of a “bump-and-hole” bromodomain-based degradation tag RP Nowak, Y Xiong, N Kirmani, J Kalabathula, KA Donovan, NA Eleuteri, ... Journal of Medicinal Chemistry 64 (15), 11637-11650, 2021 | 14 | 2021 |
| Thiazolyl-containing compounds for treating proliferative diseases NS Gray, SJ Buhrlage, SP TREON, HG Choi, Y Xiong, G Yang US Patent WO2016065138 A1, 2016 | 4 | 2016 |
| Thiazolyl-containing compounds for treating proliferative diseases NS Gray, SJ Buhrlage, SP Treon, HG Choi, Y Xiong, G Yang US Patent 10,464,949, 2019 | 3 | 2019 |
| TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence G Wu, N Yoshida, J Liu, X Zhang, Y Xiong, TB Heavican-Foral, E Mandato, ... Science translational medicine 15 (714), eadi7244, 2023 | 1 | 2023 |
| Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates HT Huang, RJ Lumpkin, RW Tsai, S Su, X Zhao, Y Xiong, J Chen, ... Nature Chemical Biology, 1-10, 2024 | | 2024 |
| HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent L Wang, S Shi, A Unterreiner, R Kapetanovic, S Ghosh, J Sanchez, ... Journal of Biological Chemistry 300 (2), 2024 | | 2024 |
| Chemoproteomic Profiling Surveys the Degradable Proteome K Donovan, F Ferguson, Y Xiong, J Bushman, N Eleuteri, N Gray, ... Journal of Biological Chemistry 299 (3), S361, 2023 | | 2023 |
| Selective hdac6 degraders and methods of use thereof ES FISCHER, Y Xiong, K DONOVAN, N ELEUTERI WO Patent WO2021092151A1, 2021 | | 2021 |
| Selective dual histone deacetylase 6/8 (hdac6/8) degraders and methods of use thereof ES FISCHER, Y Xiong, K DONOVAN, N ELEUTERI WO Patent WO2021092153A1, 2021 | | 2021 |
| Selective histone deacetylase (hdac) degraders and methods of use thereof ES FISCHER, Y Xiong, K DONOVAN, N ELEUTERI WO Patent WO2021092174A1, 2021 | | 2021 |
| Thiazolyl-containing compounds for treating proliferative diseases NS Gray, SJ Buhrlage, SP Treon, HG Choi, Y Xiong, G Yang US Patent 10,844,077, 2020 | | 2020 |
| Studies toward the total syntheses of the Sanggenon C and related natural products C Qi, Y Xiong, H Cong, J Porco ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |
Eric S FischerProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at crystal.harvard.edu
