Mathew Horrocks
Mathew Horrocks
Senior Lecturer in Biophysics, School of Chemistry, University of Edinburgh
Verified email at - Homepage
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α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, ...
Nature communications 9 (1), 2293, 2018
Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease
E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, ...
Antioxidants & redox signaling 24 (7), 376-391, 2016
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, ...
Proceedings of the National Academy of Sciences 113 (9), E1206-E1215, 2016
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, ...
Nature communications 6 (1), 7025, 2015
Ubiquitin chain conformation regulates recognition and activity of interacting proteins
Y Ye, G Blaser, MH Horrocks, MJ Ruedas-Rama, S Ibrahim, AA Zhukov, ...
Nature 492 (7428), 266-270, 2012
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, ...
Journal of cell science 129 (9), 1792-1801, 2016
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
AK Reeve, MHR Ludtmann, PR Angelova, EM Simcox, MH Horrocks, ...
Cell death & disease 6 (7), e1820-e1820, 2015
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping
MN Bongiovanni, J Godet, MH Horrocks, L Tosatto, AR Carr, ...
Nature communications 7 (1), 13544, 2016
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits
MJ Broadhead, MH Horrocks, F Zhu, L Muresan, R Benavides-Piccione, ...
Scientific reports 6 (1), 1-14, 2016
Lipid peroxidation is essential for α‐synuclein‐induced cell death
PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, ...
Journal of neurochemistry 133 (4), 582-589, 2015
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
PR Angelova, ML Choi, AV Berezhnov, MH Horrocks, CD Hughes, S De, ...
Cell Death & Differentiation 27 (10), 2781-2796, 2020
Single-molecule imaging of individual amyloid protein aggregates in human biofluids
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, ...
ACS chemical neuroscience 7 (3), 399-406, 2016
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, ...
Scientific reports 5 (1), 1-12, 2015
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, ...
Journal of Biological Chemistry 293 (12), 4486-4497, 2018
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, ...
Analytical chemistry 87 (17), 8818-8826, 2015
Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, ...
ACS chemical biology 13 (3), 636-646, 2018
SCOTfluors: small, conjugatable, orthogonal, and tunable fluorophores for in vivo imaging of cell metabolism
S Benson, A Fernandez, ND Barth, F De Moliner, MH Horrocks, ...
Angewandte Chemie 131 (21), 6985-6989, 2019
Mapping surface hydrophobicity of α-synuclein oligomers at the nanoscale
JE Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, ...
Nano letters 18 (12), 7494-7501, 2018
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, ...
BMC biology 15, 1-14, 2017
Single-molecule characterization of the interactions between extracellular chaperones and toxic α-synuclein oligomers
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, ...
Cell reports 23 (12), 3492-3500, 2018
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